15554931, images] [Full Text]" pmid="15554931"Campbell et al.(2001) determined that T lymphocytes homing to the lung in both normal and asthmatic subjects express CCR5 and CXCR3 but not CCR9 (604738), which is found on T cells homing to intestinal mucosal sites, or CLA (see SELPLG; 600738), which is found on skin-homing T cells. (2003) found that Toxoplasma gondii stimulated Il12 (161560) production not only through a Toll-like receptor/Myd88-dependent mechanism, but also through the release of an 18-k D protein, cyclophilin-18 (C18), that interacted directly with Ccr5 on DCs.8658171] [Full Text]" pmid="8658171"Alkhatib et al. (1996) reported similar observations and detected m RNA for the receptor only in cell types susceptible to macrophage-tropic isolates of HIV-1.
Although this fact could be because of insufficient virus titer, there is abundant evidence that some individuals resist infection even when directly exposed to a high titer of HIV.The regulatory sequences and noncoding exons are polymorphic, whereas the protein sequence is not. (1998) showed that polarized Th1 cells preferentially express CXCR3 (300574) and CCR5.In contrast, Th2 cells preferentially express CCR4 (604836) and, at least in a subpopulation of Th2 cells, CCR3 (601268). (1996) functionally expressed the CCR5 gene in a stably transfected CHO-K1 cell line.10823934, images] [Full Text]" pmid="10823934"Cormier et al.(2000) presented results indicating that amino acids 2-18 of the CCR5 amino-terminal domain compose a gp120-binding site that determines specificity of the interaction between CCR5 and gp120s from 2 HIV-1 isolates.